Co-Infection with Cryptosporidium meleagridis and Enterocytozoon bieneusi in an HIV+ Colombian Patient

A 44-year-old human immunodeficiency virus-infected (HIV+) female with severe Category 3 (C3) diagnosed in 2010 was admitted to hospital acute diarrhoea. She non-adherent antiretroviral therapy (ART) and had a previous suspicion of respiratory symptoms cough that been persisting for 15 days. Clinical examination revealed immune deterioration (viral load: 109,655 copies/mL; CD4+ count: 14 cells/mm3), (negative sputum Gram stain tuberculosis culture), neurological (serological assays negative Cryptococcus spp. Toxoplasma gondii). coproculture Campylobacter spp., Salmonella Shigella Ziehl–Neelsen staining faecal smears the presence Cryptosporidium oocysts. PCR testing sequencing confirmed concomitant infection C. meleagridis Enterocytozoon bieneusi. The patient treated metronidazole (500 mg every 8 h 5 days) nitazoxanide 12 days). After requesting voluntary discharge abandoning ART parasiticidal treatments, she experienced dramatic her state health contact lost. Our results have demonstrated molecular-based improves detection opportunistic pathogens are difficult detect by routine microscopy, allows transmission dynamics investigations, assists choosing best chemotherapeutical option.